Oh, that this too, too sullied flesh would melt,

Thaw, and resolve itself into a dew,

Or that the Everlasting had not fixed

His canon ‘gainst self-slaughter! O God, God!

How weary, stale, flat, and unprofitable

Seem to me all the uses of this world!

Fie on’t, ah fie! ‘Tis an unweeded garden

That grows to seed. Things rank and gross in nature

Possess it merely.

-HAMLET

“Hard to come up with a modern expression that conveys this. Fie on’t, ah fie! is an expression of disapproval or disgust; here he is cursing the misery of life and of his own life in particular, likening it to the “unweeded garden that grows to seed”.

Courtesy of Marion Burns,

http://www.proz.com/kudoz/English/poetry_literature/285261-fie_ont_ah_fie.html